{
  "id": 12575397,
  "title": "Development of inducible genetic systems to finely tune efficacy of InhA-targeting anti-tuberculous drugs",
  "url": "https://urgent.news/2026/10/07/development-of-inducible-genetic-systems-to-finely-tune-efficacy-of",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-10-07T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.25.754513v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a leading global health threat, especially due to multidrug-resistant strains. The first-line drug isoniazid (INH) and second-line drugs ethionamide (ETH) and prothionamide (PTH), are prodrugs that target the essential enoyl-ACP reductase InhA, a key enzyme involved in mycolic acid biosynthesis. Resistance to these drugs…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}