{
  "id": 12575394,
  "title": "The protective effect of NGF mutant CHF6467 in SH SY5Y cells exposed to Aβ(1-42): a pharmacometabolomic approach",
  "url": "https://urgent.news/2026/10/06/the-protective-effect-of-ngf-mutant-chf6467-in-sh-sy5y-cells-exposed",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-10-06T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.06.753538v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Nerve Growth Factor (NGF) supports neuronal survival, plasticity, and growth by binding to p75NTR and TrkA receptors. There is a strong link between NGF and the cholinergic hippocampus, and changes in NGF pathways are observed in Alzheimer's disease (AD). Research shows NGF's neuroprotective and regenerative effects on cholinergic neurons, with positive results in AD models and clinical studies.…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}