{
  "id": 12434562,
  "title": "A map of RBP-miRNA regulatory connections for deciphering the mechanisms of transcriptome remodeling in cancer",
  "url": "https://urgent.news/2026/10/06/a-map-of-rbp-mirna-regulatory-connections-for-deciphering-the",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-06T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.29.755492v1?rss=1"
  },
  "original_language": "en",
  "account": "Micro-RNAs, or miRNAs, are crucial post-transcriptional regulators of gene expression that significantly impact cancer progression and outcomes. Recent research suggests that RNA-binding proteins (RBPs) also play a significant role in post-transcriptional regulation of miRNA activity. By analyzing RNA-seq data from a wide range of RBP inhibition experiments, human cell lines, and tissues, researchers have compiled a map of regulatory connections between 34 RBPs and 28 miRNAs.\n\nAdditionally, a global analysis of miRNA abundance and activity in thousands of tumor and control samples from 17 human cancers reveals that RBP-driven regulation of miRNA activity is prevalent in tumors and contributes to the diversity in miRNA activity profiles. Specific RBPs that regulate the activity of both tumor-suppressor and oncogenic miRNAs, such as miR-29-3p, miR-17-5p, and miR-19-3p, have been identified. DDX55, a pan-cancer negative regulator of the tumor-suppressor miR-29-3p family, has been particularly noteworthy.\n\nFunctional studies demonstrate that inhibiting DDX55 restores the gene-silencing activity of miR-29-3p and decreases cancer cell viability. This study marks the first pan-cancer investigation into the functional regulatory connections between RBPs and miRNAs, emphasizing the potential for targeting RBPs as a novel strategy to reprogram abnormal miRNA activities in cancer.",
  "summary": "Micro-RNAs (miRNAs) are key post-transcriptional regulators of gene expression that influence cancer progression and outcome. Whereas transcriptional dysregulation of miRNA abundance underlies abnormal functionality of some miRNAs in cancer, emerging data points to RNA-binding proteins (RBPs) as prominent post-transcriptional regulators of miRNA activity. Here, by modelling the regulon activities…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}