{
  "id": 12427278,
  "title": "Hormonal factors are poor indicators of endometriosis pain",
  "url": "https://urgent.news/2026/10/06/hormonal-factors-are-poor-indicators-of-endometriosis-pain",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-06T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.29.755136v1?rss=1"
  },
  "original_language": "en",
  "account": "Endometriosis is a prevalent condition where sex hormones play a vital role in its development and the associated pain, yet the connection between pain and hormone levels remains unclear. In a study involving 60 women with endometriosis, researchers collected patient-reported pain intensity, interference, and a specific pain subscale. Additionally, biopsies were taken from both control and lesion tissues during surgeries to examine hormone receptor abundance. Systemic hormone levels were also analyzed. The findings revealed elevated estrogen receptor alpha (ESR1) levels in lesion tissues, but no difference in estrogen receptor beta (ESR2) levels. The study found that only ESR1 and progesterone receptor (PGR) in lesions were negatively linked to endometriosis/pelvic pain intensity. However, after adjusting for multiple comparisons, the ESR1 association lost its statistical significance. No other tissue or systemic factors were connected to clinical pain outcomes. These results indicate that endometriosis lesions exhibit distinct receptor abundance alterations, but only a few transcript levels have a weak relationship with pain in women with endometriosis.",
  "summary": "Endometriosis is a common yet understudied condition in which sex hormones play a key role in the etiology and pathophysiology of the disease. Sex hormones are dysregulated in endometriosis and are pharmacologically targeted to reduce symptoms including pain, but the relationships between endometriosis-related pain with sex hormone levels and their receptors are not clear. In 60 women previously…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}