{
  "id": 12381401,
  "title": "From Network Topology to Parameterization: An Optimized Model of Endothelial Mechanobiology",
  "url": "https://urgent.news/2026/10/06/from-network-topology-to-parameterization-an-optimized-model-of",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-06T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.10.05.756772v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Endothelial cells integrate biomechanical and biochemical cues to regulate vascular function, which can be modeled using cell signaling networks. Yet, the extent to which their signaling behavior is determined by network topology versus reaction-specific parameterization remains unclear. We developed a continuous logic-based ordinary differential equation model of vascular endothelial signaling…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}