{
  "id": 11967373,
  "title": "How blood vessels distinguish between growth and inflammation",
  "url": "https://urgent.news/2026/10/04/how-blood-vessels-distinguish-between-growth-and-inflammation",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-04T17:00:06.000Z",
  "source": {
    "name": "Medical Xpress",
    "slug": "medical-xpress",
    "url": "https://medicalxpress.com/news/2026-10-blood-vessels-distinguish-growth-inflammation.html"
  },
  "original_language": "en",
  "account": "Scientists have unraveled how blood vessels differentiate between growth and inflammation. The angiopoietin-Tie signaling pathway, crucial for healthy blood vessel maturation and maintenance, also plays a role in inflammation. Researchers found that part of the Tie1 receptor, found on endothelial cells lining blood vessels, is cleaved during inflammation. When this cleavage was prevented in genetically modified mice, their blood vessels developed normally and showed no abnormalities. However, the mice exhibited a reduced inflammatory response, with less activated blood vessels and fewer immune cells migrating into the surrounding tissue. This indicates that Tie1 cleavage is necessary for blood vessels to respond specifically to inflammatory signals. The study, published in the Journal of Clinical Investigation, reveals that Tie1 cleavage creates a functional separation between the regulation of vascular growth and vascular inflammation.",
  "summary": "The angiopoietin-Tie signaling pathway has long been known to be essential for the maturation and maintenance of healthy blood vessels. It stabilizes the vessel wall and regulates vascular growth during development. At the same time, it plays an important role in inflammation, when blood vessels become activated and immune cells leave the bloodstream and enter the surrounding tissue. How the same…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}