{
  "id": 11501729,
  "title": "What Goes on in the Brain When a Good Buzz Gets Harshed",
  "url": "https://urgent.news/2026/10/02/what-goes-on-in-the-brain-when-a-good-buzz-gets-harshed",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-02T18:30:26.000Z",
  "source": {
    "name": "Nautilus",
    "slug": "nautilus",
    "url": "https://nautil.us/what-goes-on-in-the-brain-when-a-good-buzz-gets-harshed-1285479/"
  },
  "original_language": "en",
  "account": "In 1974, Pfizer created a synthetic cannabinoid that imitated the effects of THC, but was approximately 40 times more potent. This synthetic super weed was never marketed, and instead, it is used to study the effects of THC on lab animals such as mice, as demonstrated in a new Nature study. While cannabis is often associated with relaxation, it can also induce anxiety, and now scientists may have discovered what happens in the brain during a negative experience.\n\nResearchers from Northwestern University administered varying doses of the synthetic cannabinoid, known as CP55940, to a group of mice and placed them in an enclosure containing a petri dish filled with fox urine. When confronted with the scent of a predator, mice without the influence of CP55940 approached the dish to investigate, sniffed it a few times, and then ran away. However, mice under the influence of CP55940 exhibited different behavior, resisting the urge to investigate and freezing more frequently.\n\nThis study provides valuable insight into the brain's response to a negative cannabis experience, potentially helping researchers understand the factors that contribute to anxiety during a \"bad trip.\"",
  "summary": "In 1974, Pfizer developed a synthetic cannabinoid that mimicked the effects of tetrahydrocannabinol (THC), but was around 40 times stronger. Unfortunately, this synthetic super weed was never marketed. Instead, it’s used to test the effects of THC on lab animals, like the mice in a new Nature study . Using cannabis (as you may know from firsthand experience), can be very relaxing, but it can also…",
  "key_points": [
    "Researchers studied synthetic cannabinoid CP55940's effects on mice",
    "Mice on CP55940 froze more, avoided fox urine scent",
    "Findings reveal brain response to negative cannabis experience"
  ],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}