{
  "id": 11486832,
  "title": "Why rescue-based transcript ranking can mislead: normalization displacement and shared-control coupling in perturbation transcriptomics",
  "url": "https://urgent.news/2026/10/02/why-rescue-based-transcript-ranking-can-mislead-normalization",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-02T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.27.754762v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "When a disease-associated transcript moves toward control after a phenotypically effective rescue, the pattern can be read as mediator evidence. We show why this inference can fail even when the computation is reproducible. Across normalization schemes in PLP1-mutant Jimpy brain (GSE277705), the original negative-interaction criterion classified 47.6-76.0% of all expressed genes and 77.6-86.6% of…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}