{
  "id": 11326842,
  "title": "When does post-ingestive dopamine signaling occur in humans?",
  "url": "https://urgent.news/2026/10/01/when-does-post-ingestive-dopamine-signaling-occur-in-humans",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-01T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.25.754497v1?rss=1"
  },
  "original_language": "en",
  "account": "The post-ingestive dopamine response plays a crucial role in shaping subsequent eating behavior in animals. However, assessing this response to nutrients in humans, particularly in the early post-ingestive period (30 minutes after a meal), has been challenging. Researchers conducted a secondary analysis to compare dopamine D2 receptor binding potential (D2BP) using [18F]fallypride positron emission tomography in two groups of participants who underwent controlled feeding. The study included 57 participants (66.7% female) who had fasted overnight and 43 participants (48.8% female) who had consumed a standardized meal representing 20% of their energy requirements. The results revealed that the 2-hour postprandial cohort exhibited significantly reduced whole striatal D2BP compared to the fasted group (p < .001). This suggests that post-ingestive dopamine signaling occurs within the early post-prandial period, specifically within the first 30 minutes after a meal, and plays a significant role in modulating eating behavior in humans.",
  "summary": "The post-ingestive dopamine response is an integral determinant of subsequent eating behavior in animals yet measurement of the post-ingestive response to nutrients in humans has been elusive when assessed in the early post-ingestive period (30 minutes postprandially). We conducted secondary analysis comparing dopamine D2 receptor binding potential (D2BP) measured using [18F]fallypride positron…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}