{
  "id": 11240326,
  "title": "Sex-Specific Stress Outcomes Following Acute and Chronic Social Defeat Stress",
  "url": "https://urgent.news/2026/10/01/sex-specific-stress-outcomes-following-acute-and-chronic-social",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-01T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.25.754264v1?rss=1"
  },
  "original_language": "en",
  "account": "Sex-specific stress outcomes following acute and chronic social defeat stress were investigated in this study. Researchers used a novel paired male-female social defeat paradigm, tracking subjects both acutely and chronically through stress exposure. Males exhibited changes in social avoidance/approach behavior following both acute social defeat stress (ASDS) and chronic social defeat stress (CSDS), as measured by a classic social interaction ratio. However, females displayed distinct changes in corner zone occupancy following ASDS. The study also uncovered divergent anxiety profiles between males and females in a post-stress behavioral battery. Notably, females exhibited unique stress-related locomotor responses following ASDS. These findings collectively suggest that females may adopt unique behavioral strategies in response to social defeat stress, highlighting the importance of considering sex-specific factors in stress neurobiology.",
  "summary": "Stressful experiences are a major risk factor for the development of neuropsychiatric disorders in vulnerable individuals. Identifying features that can distinguish stress-susceptible from resilient individuals remains a central goal in stress neurobiology. Due to the routine exclusion of female subjects from stress research or the use of male-defined criteria in behavioral characterization of…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}