{
  "id": 11232591,
  "title": "CD300a Blockade attenuates renal fibrosis by enhancing macrophage efferocytosis and neutrophil MMP9 production",
  "url": "https://urgent.news/2026/10/01/cd300a-blockade-attenuates-renal-fibrosis-by-enhancing-macrophage",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-10-01T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.25.754396v1?rss=1"
  },
  "original_language": "en",
  "account": "Renal fibrosis marks an irreversible stage of chronic kidney disease. While macrophage efferocytosis aids in responding to acute kidney injury, the ways early efferocytosis provides long-term protection against chronic fibrosis are unclear. Researchers discovered that deleting the inhibitory receptor CD300a (Cd300afl/flLyz2-Cre) in phagocytes helps prevent obstructive renal injury and later fibrosis. When CD300a was missing, tissue-resident macrophages improved efferocytosis in the early injury stage. This early efferocytosis reduction of damage-associated molecular patterns (DAMPs) and TGF-β expression controlled the inflammatory environment. Consequently, recruited neutrophils shifted from profibrotic SiglecF+ subsets to non-profibrotic SiglecF- subsets. Moreover, eliminating CD300a directly prepared neutrophils to produce increased matrix metalloproteinase-9 (MMP9) upon injury. However, removing neutrophils stopped the protective effect of CD300a deficiency. Notably, using a neutralizing anti-CD300a antibody in healthy mice duplicated these protective effects, promoting the shift to SiglecF- neutrophils and significantly reducing renal fibrosis. Overall, the study identifies CD300a as a factor influencing early macrophage efferocytosis and neutrophil-derived MMP9 production, suggesting that pharmacological CD300a blockade could be a potential therapy for advanced renal fibrosis.",
  "summary": "Renal fibrosis represents an irreversible endpoint of chronic kidney disease. Although macrophage efferocytosis regulates the response to acute renal injury, the mechanisms by which early efferocytosis confers long-term protection against chronic fibrosis remain elusive. Here, we show that phagocyte-specific deletion of the inhibitory receptor CD300a (Cd300afl/flLyz2-Cre) mitigates obstructive…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}