{
  "id": 11208406,
  "title": "How damaged mitochondria may contribute to liver disease",
  "url": "https://urgent.news/2026/10/01/how-damaged-mitochondria-may-contribute-to-liver-disease",
  "topic": "science",
  "section": "Science",
  "published": "2026-10-01T14:20:21.000Z",
  "source": {
    "name": "Medical Xpress",
    "slug": "medical-xpress",
    "url": "https://medicalxpress.com/news/2026-10-mitochondria-contribute-liver-disease.html"
  },
  "original_language": "en",
  "account": "Mitochondria, vital organelles providing cellular energy and participating in metabolism, have been scrutinized by researchers from the Institute of Biochemistry and Molecular Biology at Heinrich Heine University Düsseldorf and University Hospital Düsseldorf for their potential role in liver disease. A recent study published in Cell Death & Disease reveals how damaged mitochondria might contribute to early-stage liver fibrosis, a condition typically associated with advanced liver damage. The research, led by Dr. Ruchika Anand, focuses on the protein MIC13, which is crucial for organizing the mitochondrial membrane's structure, known as cristae. A disease-causing variant of MIC13 was linked to early-onset mitochondrial liver disorder called hepatoencephalopathy. To explore this connection, the team utilized stem cell-derived liver cells, engineering them to carry the disease-associated MIC13 variant. This innovative approach allowed the researchers to observe the direct impact of disrupted mitochondrial cristae on cellular metabolism. Key findings include significant alterations in amino acid, lipid, and energy metabolism, alongside increased collagen accumulation and altered cell migration in the extracellular matrix. The extracellular matrix, pivotal in tissue remodeling, indicates that mitochondrial dysfunction could instigate changes in the cellular environment at an early stage of the disease, rather than merely being a consequence of existing liver damage. These insights pave the way for deeper investigations into the mechanisms linking mitochondrial architecture, metabolism, and fibrotic remodeling, potentially identifying new therapeutic targets for mitochondrial liver disease.",
  "summary": "Mitochondria supply cells with energy, and they also play an important role in metabolism. The Institute of Biochemistry and Molecular Biology I at Heinrich Heine University Düsseldorf (HHU) and University Hospital Düsseldorf (UKD) are researching the role of mitochondria in the development of certain diseases.",
  "key_points": [
    "Damaged mitochondria may cause early liver fibrosis, not just advanced liver damage.",
    "Disease-causing MIC13 variant linked to hepatoencephalopathy, an early-onset disorder.",
    "Mitochondrial dysfunction alters amino acids, lipids, energy metabolism, and collagen accumulation."
  ],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}