{
  "id": 11127866,
  "title": "Mendel, a foundation model of human genetic variation, prioritizes regulatory variants and improves gene expression prediction",
  "url": "https://urgent.news/2026/09/30/mendel-a-foundation-model-of-human-genetic-variation-prioritizes",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-30T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.28.755183v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Human genome-wide association studies have identified hundreds of thousands of variant trait associations, but interpreting their mechanistic consequences at allele resolution remains a central bottleneck. DNA foundation models pretrained on genomic sequence corpora learn features predictive of regulatory activity, yet their training objectives are dominated by the conserved background common to…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}