{
  "id": 11064810,
  "title": "Beyond HCD: complementary fragmentation chemistries expand HLA class I immunopeptidome discovery",
  "url": "https://urgent.news/2026/09/30/beyond-hcd-complementary-fragmentation-chemistries-expand-hla-class-i",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-30T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.24.754253v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Mass spectrometry based immunopeptidomics is limited by peptide identification. HLA class I ligands are non-tryptic, frequently carry low charge states and often fragment incompletely, yet nearly all workflows rely on a single activation method, higher-energy collisional dissociation (HCD). Unlike proteomics, where a protein is inferred from several peptides, in immunopeptidomics the peptide is…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}