{
  "id": 10975000,
  "title": "Gβγ engages PLCβ3 at multiple sites to reorient and facilitate its activation",
  "url": "https://urgent.news/2026/09/30/g-engages-plc-3-at-multiple-sites-to-reorient-and-facilitate-its",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-09-30T00:00:00.000Z",
  "source": {
    "name": "eLife",
    "slug": "elife",
    "url": "https://elifesciences.org/articles/110382"
  },
  "original_language": "en",
  "account": null,
  "summary": "Phospholipase C β (PLCβ) enzymes are activated by heterotrimeric G protein subunits, increasing hydrolysis of phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) at the plasma membrane. All four human PLCβ isoforms (PLCβ1–4) are activated by Gα q , whereas PLCβ1–3 are activated to varying extents by Gβγ. The binding sites for Gα q on PLCβ are well established, and much has been learned about its…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}