{
  "id": 10930024,
  "title": "Autophagy dependent HIF1α proteostasis is compromised in models of PEX1 deficiencies",
  "url": "https://urgent.news/2026/09/30/autophagy-dependent-hif1-proteostasis-is-compromised-in-models-of",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-30T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.29.755113v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Peroxisomes, along with mitochondria, coordinate and compartmentalize oxidative metabolism in eukaryotic cells. Rare genetic disorders caused by mutations in PEX genes impair peroxisome function and cause Peroxisome Biogenesis Disorders, which are characterized by liver and neurological dysfunction, hearing and vision loss, and metabolic abnormalities. The majority of Peroxisome Biogenesis…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}