{
  "id": 10815424,
  "title": "DCMax - A novel Delayed Cmax Drug Delivery System for Improved Chronotherapy",
  "url": "https://urgent.news/2026/09/29/dcmax-a-novel-delayed-cmax-drug-delivery-system-for-improved",
  "topic": "culture",
  "section": "Culture",
  "published": "2026-09-29T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.24.753692v1?rss=1"
  },
  "original_language": "en",
  "account": "This study explored the Delayed Cmax Drug Delivery System (DCMax), a novel erosion-based controlled-release formulation aimed at delaying peak plasma concentration (Cmax) and maintaining drug release. The tablet formulation incorporated hydroxypropyl methylcellulose, hydroxypropyl methylcellulose acetate succinate, and polyethylene oxide. Through in-vitro dissolution and erosion tests, the delayed release profile of DCMax was validated. To evaluate the in-vivo performance, the study involved six healthy volunteers who underwent salivary caffeine concentration measurements following the ingestion of either immediate-release caffeine tablets or DCMax tablets. The results indicated that DCMax induced a significant delay in Cmax by 5 hours, as opposed to the 1-hour peak observed with the immediate-release formulation. Furthermore, the peak caffeine concentrations in saliva were lower when using DCMax compared to the immediate-release option. These findings underscore the potential of erosion-based drug delivery systems in achieving delayed release, which could hold promise for chronotherapy applications in treating endocrine disorders.",
  "summary": "This study evaluated the Delayed Cmax Drug Delivery System (DCMax), an erosion-based controlled- release formulation designed to delay peak plasma concentration (Cmax) and sustain drug release. The tablet matrix contained hydroxypropyl methylcellulose, hydroxypropyl methylcellulose acetate succinate, and polyethylene oxide. In-vitro dissolution and erosion studies confirmed the delayed release…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}