{
  "id": 10808405,
  "title": "Deciphering the gene-centric spatial dynamics across tissue and time with GeneSPOT",
  "url": "https://urgent.news/2026/09/29/deciphering-the-gene-centric-spatial-dynamics-across-tissue-and-time",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-29T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.24.753111v1?rss=1"
  },
  "original_language": "en",
  "account": "Spatial omics technologies enable detailed investigation of molecular programs within tissues. Existing analytical methods, however, focus mainly on identifying cellular states and differentially expressed molecular features. The spatial organization and dynamics of molecular features across biological contexts have not been extensively explored. We introduce GeneSPOT, a gene-centric computational approach to characterize spatial relationships among genes and quantify their reorganization across conditions. While designed to focus on genes, GeneSPOT is applicable to other molecular entities. Across various applications, GeneSPOT successfully identified tissue structures, integrated both paired and unpaired spatial multi-omics data, revealed the spatial convergence of gene programs during embryonic development, and detected aging-associated reorganization of genes with age-unchanged expression. By complementing conventional cell-centric analysis, GeneSPOT offers a framework to decipher how spatial relationships among molecular features adapt across biological conditions and time.",
  "summary": "Spatial omics technologies provide unprecedented opportunities to investigate how molecular programs are organized within tissues. However, existing analytical frameworks primarily focus on identifying cellular states and characterizing differentially expressed molecular features across these states. The relational spatial organization of molecular features and its dynamics across biological…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}