{
  "id": 10713001,
  "title": "The molecular mechanism that regulates TMEM63B lipid scrambling",
  "url": "https://urgent.news/2026/09/29/the-molecular-mechanism-that-regulates-tmem63b-lipid-scrambling",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-29T14:20:17.000Z",
  "source": {
    "name": "Phys.org",
    "slug": "phys-org",
    "url": "https://phys.org/news/2026-09-molecular-mechanism-tmem63b-lipid-scrambling.html"
  },
  "original_language": "en",
  "account": null,
  "summary": "TMEM63B, a mechanosensitive lipid scramblase, has an autoinhibitory domain in its C-terminal tail that helps keep it inactive under resting conditions, researchers from the Institute of Science Tokyo report. Changes to this regulatory region, particularly the Leu776 residue, reverse the inhibitory action and cause continuous lipid scrambling, disrupting normal phospholipid asymmetry.",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}