{
  "id": 10608246,
  "title": "Unified modeling of mutation-induced protein stability responses with OmegaTherm",
  "url": "https://urgent.news/2026/09/28/unified-modeling-of-mutation-induced-protein-stability-responses-with",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-28T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.23.753709v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Accurate prediction of mutation-induced protein stability responses, including changes in folding free energy and melting temperature, is critical for protein engineering. Existing models represent these related but non-equivalent measurements separately and often focus on single mutations. Here we present OmegaTherm, a sequence-based framework that jointly learns both stability responses for…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}