{
  "id": 10601448,
  "title": "Agentic transcranial functional ultrasound imaging: @fUS",
  "url": "https://urgent.news/2026/09/28/agentic-transcranial-functional-ultrasound-imaging-fus",
  "topic": "ai",
  "section": "AI",
  "published": "2026-09-28T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.25.752961v1?rss=1"
  },
  "original_language": "en",
  "account": "Functional ultrasound (fUS) imaging offers deep, wide-field access to brain function, yet its high instrument cost and intricate acquisition and analysis workflows limit its broader use. Researchers have now unveiled @fUS, a novel agentic transcranial imaging platform featuring an open architecture that merges specialized hardware with experimental tools and structured memory. This system employs 128-channel, 16-bit acquisition at 125 MHz, accompanied by GPU-based processing, allowing for functional imaging through a live mouse's intact scalp and skull. With roughly 100-m spatial resolution and 10-Hz temporal sampling, @fUS lays the groundwork for longitudinal studies without the need for cranial-window surgery. The platform's agent orchestrates the connection between scientific goals and experimental design, direct instrument control, and data analysis. It maintains context across interactions and enables inspectable workflows via text and voice commands. Neuroscience trainees with minimal engineering expertise managed to configure the system independently within just 30 minutes. By leveraging agent-assisted exploration of whisker-stimulation datasets, @fUS uncovered low-frequency vascular alterations that traditional response mapping missed, corroborated by parallel two-photon measurements of individual vessel diameter. By merging transcranial imaging with user-friendly instrument control and analysis, @fUS lays a solid foundation for wider adoption and the generation of larger, more diverse neuroscience datasets. More fundamentally, it provides a framework for scientific instruments, where measurement, computation, and experimental reasoning are seamlessly integrated into a single system.",
  "summary": "Functional ultrasound (fUS) imaging provides deep, wide-field access to brain function, but instrument cost and complex acquisition and analysis workflows restrict its wider adoption. Here we introduce @fUS, an agentic transcranial imaging platform with an open architecture that integrates purpose-built hardware with executable experimental skills and persistent structured memory. The system…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}