{
  "id": 10553544,
  "title": "Hypothalamic Farnesoid X Receptor deficiency alters energy balance by modulating hepatic glucose production and adipose tissue metabolism through central insulin signaling.",
  "url": "https://urgent.news/2026/09/28/hypothalamic-farnesoid-x-receptor-deficiency-alters-energy-balance-by",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-09-28T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.21.753141v1?rss=1"
  },
  "original_language": "en",
  "account": "Researchers have uncovered a new role for the hypothalamic Farnesoid X Receptor (FXR) in regulating energy balance. FXR, a bile acid nuclear receptor, is known to be a major regulator of metabolism and energy homeostasis in peripheral organs, influencing glucose, lipid metabolism, and body weight. While its brain function was previously linked to energy balance, the specific role of FXR in the hypothalamus was unclear. To investigate this, researchers used a genetic approach to study the effects of hypothalamic FXR deficiency on metabolic parameters related to energy homeostasis. The results showed that the lack of FXR in the hypothalamus led to a positive energy balance, characterized by reduced energy expenditure and alterations in glucose metabolism. This was accompanied by structural changes in white adipose tissue. The study concludes that hypothalamic FXR plays a previously unrecognized role in the central control of energy balance, shedding light on its contribution to glucose metabolism and adipose tissue remodeling.",
  "summary": "Objectives: The bile acid nuclear receptor Farnesoid X Receptor (FXR, NR1H4) is a major regulator of metabolism and energy homeostasis in peripheral organs. It modulates bile acid, glucose, and lipid metabolism, as well as fat mass and body weight. However, FXR is also expressed in the brain, particularly in the hypothalamus, a key center for the regulation of energy homeostasis. Although one…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}