{
  "id": 10458255,
  "title": "A high-throughput screening dataset of small-molecule inhibitors across human DNA glycosylases",
  "url": "https://urgent.news/2026/09/28/a-high-throughput-screening-dataset-of-small-molecule-inhibitors",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-28T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.25.752594v1?rss=1"
  },
  "original_language": "en",
  "account": "A comprehensive dataset of small-molecule inhibitors targeting human DNA glycosylases has been developed through collaborative efforts spanning Scandinavia. This high-throughput screening assay platform enables the systematic evaluation of compounds against nine glycosylases, yielding valuable primary screening and concentration-response data. The screening process identified several novel inhibitors, some of which had not been reported previously. The dataset includes all primary and processed data, along with comprehensive assay protocols and metadata, and is openly accessible for reuse in chemical biology research, compound optimization, assay development, and comparative studies of DNA repair enzymes.",
  "summary": "The base excision repair pathway removes small base lesions from DNA and is initiated in humans by one of eleven DNA glycosylases with overlapping substrate specificities. Despite their central role in genome maintenance and transcription, systematic datasets describing small-molecule binders or inhibitors of DNA glycosylases are lacking. Here, through a collaborative effort across Scandinavia,…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}