{
  "id": 10458250,
  "title": "A druggable chromatin vulnerability in suppressive neutrophils restores antitumor immunity",
  "url": "https://urgent.news/2026/09/28/a-druggable-chromatin-vulnerability-in-suppressive-neutrophils",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-28T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.26.754703v1?rss=1"
  },
  "original_language": "en",
  "account": "Cancer cells can bypass immunity by transforming neutrophils into myeloid-derived suppressor cells (PMN-MDSCs). However, the chromatin mechanisms behind this suppression are not well understood. Researchers have discovered that mSWI/SNF chromatin remodeling plays a crucial role in maintaining these pathological neutrophils. They found that two orally active mSWI/SNF ATPase antagonists, a degrader and a catalytic inhibitor, can restore antitumor immunity in various cancer models, even those resistant to PD-1 blockade and to checkpoint therapy. These treatments quickly eliminated intratumoral PMN-MDSCs, revived functional CD8+ T cells, and blocked the expansion and suppressive effects of PMN-MDSCs in both mouse and human samples. Moreover, mSWI/SNF antagonism altered chromatin accessibility and reduced PU.1/C/EBPβ occupancy at regulatory elements that sustain PMN-MDSC identity. Therefore, this chromatin vulnerability in suppressive neutrophils may be targeted with drugs to enhance cancer immunity.",
  "summary": "Many cancers evade immunity by converting neutrophils into polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs), but the chromatin mechanisms that maintain this pathological state remain unclear. Here we show that tumor-induced suppressive neutrophils depend on mSWI/SNF chromatin remodeling. Two orally bioavailable mSWI/SNF ATPase antagonists, a degrader and a catalytic inhibitor,…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}