{
  "id": 10458249,
  "title": "Integrated immunopeptidomics and transcriptomics reveal a cancer-restricted non-canonical HLA class I ligandome in medulloblastoma",
  "url": "https://urgent.news/2026/09/28/integrated-immunopeptidomics-and-transcriptomics-reveal-a-cancer",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-09-28T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.26.754718v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Medulloblastoma is the leading type of malignant brain tumor in children. Despite recent advances in T cell-based immunotherapy, the low mutational burden of medulloblastoma poses a considerable challenge to the discovery of mutation-derived neoantigens. Previous studies of medulloblastoma have investigated tumor-associated antigens and neoantigens derived from aberrant splice junctions. The…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}