{
  "id": 10446053,
  "title": "How missing pieces of the Y chromosome drive cancer in men",
  "url": "https://urgent.news/2026/09/28/how-missing-pieces-of-the-y-chromosome-drive-cancer-in-men",
  "topic": "health",
  "section": "Health & Medicine",
  "published": "2026-09-28T13:00:10.000Z",
  "source": {
    "name": "Medical Xpress",
    "slug": "medical-xpress",
    "url": "https://medicalxpress.com/news/2026-09-pieces-chromosome-cancer-men.html"
  },
  "original_language": "en",
  "account": null,
  "summary": "A new study has found that cancer cells selectively chip away at gene-rich sections of the Y chromosome, triggering changes that regulate tumor growth. Led by Dr. Dan Theodorescu from the University of Arizona Cancer Center, the paper titled \"Recurrent deletions and regulatory disruption of the Y chromosome in cancer\" was published in Communications Biology. The study analyzed genome sequencing and gene expression data from 160 male cell lines and discovered that cancer cells lose specific, gene-rich regions of the Y chromosome to aid tumor growth while keeping other regions intact. Researchers identified 24 protein-coding genes on the Y chromosome that were recurrently lost, with 15 of these genes also found to be lost in external datasets. The findings show that these Y chromosome losses are acquired over time rather than inherited traits, and understanding which parts are lost could lead to targeted therapies for patients.",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}