{
  "id": 10406847,
  "title": "Senescence-associated KRAS upregulation in peripheral T cells links to premature coronary artery disease",
  "url": "https://urgent.news/2026/09/28/senescence-associated-kras-upregulation-in-peripheral-t-cells-links",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-28T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.22.753659v1?rss=1"
  },
  "original_language": "en",
  "account": "Premature coronary artery disease (PCAD) may be linked to age-related gene dysregulation in T cells, according to a recent study. The researchers investigated whether changes in T cell genes associated with aging could contribute to PCAD. Using various molecular biology techniques, they identified the KRAS gene as a key player in this connection. KRAS was found to be upregulated in effector CD8+ T cells, which are the cells most prone to aging-related senescence. These senescent T cells also showed higher levels of KRAS. The study's findings suggest that KRAS-high effector CD8+ T cells are present in coronary and carotid plaques, which are common in PCAD. These cells display enhanced cytotoxicity, exhaustion, and senescence features. The researchers also used a computational approach to predict a small molecule that could potentially bind to inactive KRAS. This discovery could lead to a new biomarker for PCAD and a potential therapeutic target for further research.",
  "summary": "Aims: Premature coronary artery disease (PCAD) lacks specific molecular drivers, and the role of immunosenescence is unclear. We investigated whether aging-related gene dysregulation in T cells contributes to PCAD. Methods: We combined bulk transcriptomics of PBMCs from 12 PCAD patients and 21 controls, single-cell RNA sequencing of PBMCs and human atherosclerotic plaques, weighted gene…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}