{
  "id": 10162343,
  "title": "Different hippocampal subfield volumes predict source memory performance and general cognitive ability in an adult lifespan sample",
  "url": "https://urgent.news/2026/09/27/different-hippocampal-subfield-volumes-predict-source-memory",
  "topic": "science",
  "section": "Science",
  "published": "2026-09-27T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.09.25.754488v1?rss=1"
  },
  "original_language": "en",
  "account": "A recent study explored the relationship between specific hippocampal subfield volumes and cognitive abilities in a group of cognitively healthy adults aged between 18 and 87 years. Researchers utilized high-resolution structural images to measure the volume of four hippocampal subfields: Cornu Ammonis (CA)1, CA2-3, dentate gyrus (DG), and subiculum. Principal components analysis was applied to reduce the neuropsychological test scores into five cognitive components, with two components reflecting memory performance and the remaining three representing various aspects of non-mnemonic cognition.\n\nThe findings revealed that source memory performance exhibited a selective association with the volume of the CA2-3 subfield. In contrast, both mnemonic and non-mnemonic component scores derived from the comprehensive neuropsychological test battery were associated exclusively with the volume of the DG. This association remained consistent across different ages, indicating that these cognitive domains can be dissociated based on their relationships with different hippocampal subfields. The researchers concluded that these associations appear to be lifelong, suggesting that they are unlikely to be influenced by age-related decline in structural integrity.",
  "summary": "Modest positive associations between episodic memory performance and whole hippocampal and hippocampal subfield volumes have been reported in numerous prior studies. A smaller number of studies have reported associations between hippocampal volume and performance on tests of non-mnemonic cognition. The present study examined whether these associations were evident in a lifespan sample of…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}