{
  "id": 1000946,
  "title": "Focused framework sampling recovers binding-positive humanized anti-amyloid-β antibodies in a single sorting round",
  "url": "https://urgent.news/2026/08/15/focused-framework-sampling-recovers-binding-positive-humanized-anti",
  "topic": "science",
  "section": "Science",
  "published": "2026-08-15T00:00:00.000Z",
  "source": {
    "name": "bioRxiv",
    "slug": "biorxiv",
    "url": "https://www.biorxiv.org/content/10.64898/2026.08.14.744767v1?rss=1"
  },
  "original_language": "en",
  "account": null,
  "summary": "Therapeutic antibody development requires workflows that integrate antigen-reactive clone discovery with efficient humanization and early developability assessment. Here, we combined immune yeast fragment antigen-binding (Fab) display with single-round focused humanization and applied the workflow to antibodies against amyloid-beta (Abeta)-derived preparations. Immunization with Abeta1-42…",
  "key_points": [],
  "editors_take": null,
  "illustration": null,
  "coverage": {
    "outlets": 1,
    "also_reported_by": []
  },
  "ai_generated": true,
  "disclaimer": "Summaries, key points and the editor’s take are written by software from other outlets’ reporting and may contain errors — always check the linked original."
}